Program – Inflammatory Skin Disease Summit 2018

(as per December 11th, 2018)

WEDNESDAY, DECEMBER 12, 2018

14.00	Registration opens
Opening	Session chairs afternoon: Emma Guttman (New York, USA) Patrick M. Brunner (Vienna, Austria)
16.00 – 16.10	Welcome address
16.10 – 16.35	Setting the stage – Historic perspectives Georg Stingl (Vienna, Austria)
16.35 – 17.00	Setting the stage – The translational revolution in inflammatory skin diseases James G. Krueger (New York, NY, USA)
17.00 –17.30	Two sides of Th17 cells in autoimmunity and tissue homeostasis Vijay Kuchroo (Boston, MA, USA)
	Session chairs evening: Erwin Tschachler (Vienna, Austria) Luis Puig (Barcelona, Spain)
17.30 – 18.30	Oral presentations from selected abstracts #125 Selective oral JAK3 and TYK2/JAK1 kinase inhibitors both demonstrate significant hair-growth compared to placebo and improvement of hair-associated keratins in patients with moderate-to-severe Alopecia Areata. Emma Guttman (New York, USA) #130 A selective inhibitor of TYK2, BMS-986165, improves molecular, cellular, and clinical biomarkers associated with efficacy in moderate-to-severe psoriasis. Ian M. Catlett (Princeton, USA) #86 A Phase 2A, randomised, double-blind, placebo-controlled study to evaluate efficacy and safety of PF-06700841 in patients with moderate-to-severe plaque psoriasis. Seth Forman (Tampa, USA) #123 New innovative approach combining comparative transcriptomics from three unique psoriasis models to identify predictive PsA biomarkers. Johann Gudjonsson (Ann Arbor, USA) #LB4 Guselkumab demonstrates superior long-term responses to secukinumab at Week48 in the treatment of moderate to severe psoriasis: Results from the ECLIPSE trial Richard Langley (Halifax, Canada)
18.30 – 21.00	Poster viewing and networking

THURSDAY, DECEMBER 13, 2018

	Session chairs morning: Sylvia Knapp (Vienna, Austria) Michael Detmar (Zurich, Switzerland)
08.30 – 9.00	A perspective of dendritic cells in inflammatory skin diseases Thomas Bieber (Bonn, Germany)
09.00 – 09.30	Resident T cells in health and disease Rachael Clark (Boston, MA, USA)
09.30 – 10.00	T cell subsets across inflammation and cancer Thomas S. Kupper (Boston, MA, USA)
10.00 – 10.30	Innate lymphoid cells in health and disease Graham Ogg (Oxford, United Kingdom)
10.30 – 10.45	Oral presentations from selected abstracts #112 Resident T cells trigger disease-associated tissue responses that stratify clinical outcome in human psoriasis. Liv Eidsmo (Stockholm, Sweden)
10.45 – 11.00	BREAK
11.00 – 12.30	Does Psoriasis Treatment Alter the Risk of Comorbidities? Examining the Evidence Symposium supported by Eli Lilly Chair: Kilian Eyerich (Munich, Germany)Psoriasis and Comorbidities: An Overview Kilian Eyerich (Munich, Germany) The Role of Cytokines in the Pathogenesis of Psoriasis and Associated Comorbidities Patrick Brunner (Vienna, Austria) Does Psoriasis Treatment affect Cardiovascular Disease? Joel Gelfand (Philadelphia, PA, USA) Psoriasis and Psyche: What Do We Know? Kristian Reich (Berlin, Germany) Panel Discussion and Audience Q&A: Implications for Psoriasis Management All faculty Concluding Remarks and Close Kilian Eyerich (Munich, Germany)
12.30 – 13.00	BREAK
	Session chairs afternoon: Donald Leung (Denver, USA) Stefanie Eyerich (Munich, Germany)
13.00 – 14.00	Oral presentations from selected abstracts #138 Blood endotyping distinguishes the profile of vitiligo from other inflammatory and autoimmune skin diseases. Tali Czarnowicki (New York, USA) #102 Low-input RNA sequencing reveals survival program of human skin-resident T cells during complete myeloablation. Johanna Strobl (Vienna, Austria) #78 A critical role for IL-37 in regulatory T cell maintenance and CD4+ T cell inhibition. Mayumi Fujita (Aurora, USA) #70 KLK6-PAR1 signaling drives psoriasiform manifestations in skin and bone and blockade of PAR1 in explanted psoriasis patient skin decreases key psoriasis transcripts. Nicole Ward (Cleveland, USA)
14.00 – 14.30	Protective immunity and immunodeficiencies Jean-Laurent Casanova (New York, NY, USA)
14.30 – 15.30	COFFEE BREAK
	Session chairs late afternoon: Dirk Jan Hijnen (Rotterdam, The Netherlands) Adelheid Elbe-Bürger (Vienna, Austria)
15.30 – 16.00	Janus kinases in inflammation Massimo Gadina (Bethesda, MD, USA) on behalf of John O’Shea (Bethesda, MD, USA)
16.00 – 16.30	Visualization of skin inflammation and resulting immunologic concepts Kenji Kabashima (Kyoto, Japan)
16.30– 17.00	The microbiome and therapeutic implications Richard Gallo (San Diego, CA, USA)
17.00-17.30	Oral presentations from selected abstracts #74 Triple correlation between skin microbiome, skin barrier and immune gene expression pathways in atopic dermatitis. Claudia Traidl-Hoffmann (Augsburg, Germany) #45 Baseline inflammatory biomarker profiles and clinical heterogeneity of adult patients with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids. Brian Nickoloff (Indianapolis, USA)

Official Networking Evening

FRIDAY, DECEMBER 14, 2018

08.00 – 09.30	Discover the potential: exploring new frontiers of IL-23 inhibitors Symposium supported by Janssen Chair: Antonio Costanzo (Milano, Italy) & Kilian Eyerich (Munich, Germany) Welcome and introduction Antonio Costanzo (Milano, Italy) Advancing the science of psoriasis: the underlying pathology and the role IL-23 Antonio Costanzo (Milano, Italy) New horizons in managing psoriasis: individualizing care one patient at a time Kilian Eyerich (Munich, Germany) Interactive Q&A session Antonio Costanzo (Milano, Italy) & Kilian Eyerich (Munich, Germany) Summary and closing Kilian Eyerich (Munich, Germany)
09.30 – 09.45	BREAK
	Session chairs morning: Stephan Weidinger (Kiel, Germany) James T. Elder (Ann Arbor, Michigan)
09.45 – 10.15	How to perform successful clinical trials in inflammatory skin diseases Kristian Reich (Hamburg, Germany)
10.15 – 10.45	Framing psoriasis James G. Krueger (New York, NY, USA)
10.45 – 11.15	Autoantigens in psoriasis Michel Gilliet (Lausanne, Switzerland)
11.15 – 11.45	Impact of immune targeted therapy on cardiovascular risk: The psoriasis model Joel Gelfand (Philadelphia, PA, USA)
11.45 – 12.00	BREAK
12.00 – 13.30	THE GREAT DEBATE: Should the Treatment Paradigm for Mild to Moderate Atopic Dermatitis (AD) Evolve? Symposium supported by Pfizer Moderator: Charles Lynde (Ontario, Canada) Invited Speaker: Aviv Barzilai (Tel Aviv, Israel) Invited Speaker: Adelaide A. Hebert (Houston,TX, USA) Invited Speaker: Torsten Zuberbier (Berlin, Germany)
13.30 – 13.45	BREAK
	Session chairs afternoon: Matthias Schmuth (Innsbruck, Austria) Zuhair Ballas (Iowa City, USA)
13.45 – 14.15	Inflammatory profile of atopic dermatitis and cytokine targeted treatments Emma Guttman (New York, NY, USA)
14.15 – 14.45	Barrier defects in atopic dermatitis and prevention strategies Alan Irvine (Dublin, Ireland)
14.45 – 15.15	Atopic dermatitis at disease onset Patrick M. Brunner (Vienna, Austria)
15.15 – 15.45	Adopting Orphan Ichthyoses: New Focus for Inflammatory Skin Research Amy S. Paller (Chicago, IL, USA)
15.45 – 16.15	COFFEE BREAK
	Session chairs late afternoon: Alain Hovnanian (Paris, France) Tove Agner (Copenhagen, Denmark)
16.15 – 16.45	Epicutaneous antigen desensitization Christophe Dupont (Paris, France)
16.45 –17.15	Peripheral tolerance to autoimmune target in pemphigus Masayuki Amagai (Tokyo, Japan)
17.15-18.05	Oral presentations from selected abstracts #48 Conjunctival inflammation and loss of goblet cells in atopic dermatitis patients treated with dupilumab in daily practice. Daphne Bakker (Utrecht, Netherlands) #90 Proteomics analysis shows that non-invasive epidermal sampling is a robust diagnostic approach for inflammatory skin diseases. Anna Berekmeri (Leeds, United Kingdom) #67 Major differences in expression of inflammatory products in skin from different body sites of healthy individuals. Ester Del Duca (New York, USA) #21 Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin micro environment Christina Zielinski (Munich, Germany)

SATURDAY, DECEMBER 15, 2018

08.00 – 09.30	Atopic Dermatitis and Beyond: Pathogenic and Therapeutic Advances Symposium supported by Sanofi Genzyme Introduction Emma Guttman (New York, USA) Atopic Dermatitis: Emerging as a cytokine-driven disease and novel therapeutic developments Emma Guttman (New York, USA) Pediatric atopic dermatitis–pathogenic and therapeutic advances and implications for the atopic march Patrick Brunner (Vienna, Austria) Th2 Inhibition beyond atopic dermatitis Frank O. Nestle (Boston, USA) Panel Discussion Emma Guttman, Frank O. Nestle, Patrick Brunner
09.30 – 09.45	BREAK
	Session chairs morning: Amos Gilhar (Haifa, Israel) Thomas Luger (Münster, Germany)
09.45 – 10.00	Oral presentations from selected abstracts #120 Massive expansion of drug-specific, clonotypic and polycytotoxic CD8+ T cells in Toxic Epidermal Necrolysis. Marc Vocanson (Lyon, France)
10.00 – 10.30	Alopecia areata Ralf Paus (Manchester, UK)
10.30 – 11.00	Acne & Rosacea Martin Steinhoff (Dublin, Ireland)
11.00 – 11.30	Vitiligo John Harris (Worchester, MA, USA)
11.30 – 12.00	COFFEE BREAK
	Session chairs afternoon: Peter Wolf (Graz, Austria) Daniel Aletaha (Vienna, Austria)
12.00 – 12.30	Eosinophilic disorders Bruce Bochner (Chicago, IL, USA)
12.30 – 13.00	Adding new pieces to the old Lupus puzzle Virginia Pascual (New York, NY, USA)
13.00 – 13.30	Dermatomyositis: Pearls, Pitfalls, and an Evolving Therapeutic Landscape Ruth Ann Vleugels (Boston, MA, USA)
	Session chairs late afternoon: Robert Bissonnette (Montreal, Canada) Matthias Augustin (Hamburg, Germany)
13.30 – 14.20	Oral presentations from selected abstracts #117 Early Improvement in Pruritus and Reduction in Clinical Signs in a Phase 2a Mechanism of Action Study of Crisaborole in Mild to Moderate Atopic Dermatitis. Robert Bissonnette (Montreal, Canada) #30 A Topical Nitric Oxide-Releasing Cream SB414: Results of a Phase 1b Double-Blind, Randomized, Vehicle-Controlled Study in Patients with Mild-to-Moderate Atopic Dermatitis. Tomoko Maeda-Chubachi (Morrisville, USA) #88 Topical DS107 for the treatment of mild-to-moderate Atopic Dermatitis: Results from ADVANTAGE, an 8 week phase 2b randomized, double-blind, vehicle-controlled study. Moayed Hamza (Dublin, Ireland) #103 Cerdulatinib (DMVT-502), a novel, topical dual Janus kinase/spleen tyrosine kinase inhibitor, improves the cellular and molecular cutaneous signature in patients with atopic dermatitis. Anna Tallman (New York, USA)
14.20 – 14.30	Closing session

Confirmed speakers (as per December 11, 2018):

Masayuki Amagai, Tokyo, Japan – Peripheral tolerance to autoimmune target in pemphigus

Thomas Bieber, Bonn, Germany – Dendritic cells in inflammatory skin diseases

Bruce Bochner, Chicago, IL – Eosinophilic disorders

Patrick M. Brunner, Vienna, Austria – Atopic dermatitis at disease onset

Jean-Laurent Casanova, New York, NY – Protective immunity and immunodeficiencies

Rachael Clark, Boston, MA – Resident T cells in health and disease

Christophe Dupont, Paris, France – Epicutaneous antigen desensitization

Massimo Gadina, Bethesda, MD – Janus kinases in inflammation

Richard Gallo, San Diego, CA – The microbiome and therapeutic implications

Joel Gelfand, Philadelphia, PA – Impact of immune targeted therapy on cardiovascular risk: The psoriasis model

Michel Gilliet, Lausanne, Switzerland – Autoantigens in psoriasis

Emma Guttman, New York, NY – Inflammatory profile of atopic dermatitis and cytokine targeted treatments

John Harris, Worcester, MA – Vitiligo

Alan Irvine, Dublin, Ireland – Barrier defects in AD and prevention strategies

Kenji Kabashima, Kyoto, Japan – Visualization of skin inflammation and resulting immunologic concepts

James G. Krueger, New York, NY – Framing psoriasis

Vijay Kuchroo, Boston, MA – Two sides of Th17 cells in autoimmunity and tissue homeostasis

Thomas Kupper, Boston, MA – T cell subsets across inflammation and cancer

Graham Ogg, Oxford, UK – Innate lymphoid cells in health and disease

Amy S. Paller, Chicago, IL – Adopting orphan ichthyoses: New focus for inflammatory skin research

Virginia Pascual, New York, NY – Adding new pieces to the old Lupus puzzle

Ralf Paus, Manchester, UK – Alopecia areata

Kristian Reich, Hamburg, Germany – How to perform successful clinical trials in inflammatory skin diseases

Martin Steinhoff, Dublin, Ireland – Acne & Rosacea

Georg Stingl, Vienna, Austria – Historic perspective

Ruth Ann Vleugels, Boston, MA – Collagenoses

11.00 – 11.10	Psoriasis and Comorbidities: An Overview Eyerich, Kilian, Munich, Germany
11.10 – 11.25	The Role of Cytokines in the Pathogenesis of Psoriasis and Associated Comorbidities Brunner, Patrick, Vienna, Austria
11.25 – 11.45	Does Psoriasis Treatment affect Cardiovascular Disease? Joel Gelfand, Philadelphia, PA, USA
11.45 – 12.05	Psoriasis and Psyche: What Do We Know? Kristian Reich, Berlin, Germany
12.05 – 12.25	Panel Discussion and Audience Q&A: Implications for Psoriasis Management All faculty
12.25 – 12.30	Concluding Remarks and Close Eyerich, Kilian, Munich, Germany

08.30 – 08.35	Welcome and introduction Antonio Costanzo, Milano, Italy
08.35 – 08.55	Advancing the science of psoriasis: the underlying pathology and the role IL-23 Antonio Costanzo, Milano, Italy
08.55 – 09.15	New horizons in managing psoriasis: individualizing care one patient at a time Kilian Eyerich, Munich, Germany
09.15 – 09.25	Interactive Q&A session Antonio Costanzo, Milano, Italy & Kilian Eyerich, Munich, Germany
09.25 – 09.30	Summary and closing Kilian Eyerich, Munich, Germany

08.00 – 08.10	Introduction Emma Guttman, New York, USA
08.10 – 08.35	Atopic Dermatitis: Emerging as a cytokine-driven disease and novel therapeutic developments Emma Guttman, New York, USA
08.35 – 08.55	Pediatric atopic dermatitis–pathogenic and therapeutic advances and implications for the atopic march Patrick Brunner, Vienna, Austria
08.55 – 09.20	Th2 Inhibition beyond atopic dermatitis Frank O. Nestle, Boston, USA
09.20 – 09.30	Panel Discussion Emma Guttman, Frank O. Nestle, Patrick Brunner

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